Endocrine Abstracts

Reports in the literature have demonstrated an increased number of nerve fibers and the presence of a follicle development similar to polycystic ovary during perimenopausal ovary in women. Since differentiation, proliferation and growth of nerves depends of nerve growth factor (NGF), changes in the content of nerves fiber could be preceded by increases in NGF and p75 neurotrophin receptor (p75NTR). Our purpose was to evaluate the changes in noradrenaline (NA) at the celiac gan...

The reprogramming effects of an excess of testosterone during pregnancy in males born to PCOS mothers as well as in animal models for PCOS has been only recently evaluated. We have found in a sheep model of PCOS that prenatal T (PT) excess impact on the testis of adults with increased Sertoli cell (SC) number, decreased sperm count, and reduced germ cell (GC) number. The ontogeny of such disruptions and the mechanisms have not been established. This study addressed the impact ...

Our previous study showed that polycystic ovary syndrome (PCOS)-like reproductive and metabolic phenotypes induced by maternal dihydrotestosterone (DHT)-exposure, can be passed on in mice from mothers (F0) to daughters (F1), granddaughters (F2), and even to great-granddaughters (F3). The female transmission is independent of diet-induced obesity and is mediated by transcriptional and mitochondrial perturbations of oocytes accompany. ...